Dr. Keith D. Wing

Keith D. Wing Consulting, LLC

 

Member profile details

Photo
First name
Dr. Keith D.
Last name
Wing
Organization
Keith D. Wing Consulting, LLC
 

Contact information

Address
122 Yardley Lane
City
Wilmington
State
Delaware
Zip Code
19810
Country
United States
Phone
(302)740-6683
Alternate Web Site
 

Specialties and Services

Fields of Expertise
  • Agricultural
  • Analytical
  • Biochemistry
  • Biotechnology
  • Competitive Intelligence
  • Green Chemistry
  • Literature and Patent Searches
  • Patents
  • Product Development
  • Project Management
  • Research and Development
Other Fields of Expertise
Life Science Biochemistry Biochemicals Biomass Agrochemicals Agrichemicals Insecticides Biomass Biofuels Strategic Planning
Renewable Sustainable Chemistry
Soy Soybean
Bioprocessing
Industrial Biotechnology
Summary
- Flexibility to solve new problems from project issues to strategic planning
- Recipient 2015 Amer. Chem. Soc. AGRO Division International Award for Agrochemical Research, for lifetime achievements in insecticide commercialization and science. Recipient of other lifetime ACS, DuPont and Rohm and Haas science/business awards.
- Professional, highest integrity
- Solutions custom fit to your business and organization.
- Experience, breadth and depth, consistent value delivery.
- Publication and patent record of continuous productivity: 3 papers in Science
- Willing to act as expert witness - national or international
Services
Technology Enhancement

- New technology/opportunity assessment (for your business directly, competitor or acquisition target)
- Assess innovative product opportunities
- Prepare case for new product based on your company's technologies
- IP and/or technology transfer assistance
- Advice on deals

Technical Problem Solving

- Address issue with a current lead, product, technology or project
- Provide a constructive, business-focused outside perspective
- New or improved ways to assay or measure a critical bioprocess, and link to structure-activity
- Gain insights into the mode of action, metabolism or transport of your molecule of interest
- Gain insights into resistance issues
- Expert witnessing

Strategic Planning
- Assist in replotting the course of your organization's R&D, to enhance value
- Provide a new approach to strategic directions, attempting to maximize gain while limiting risk
- Provide new ideas or leads to feed your discovery pipeline
- Assess the mix of disciplines on your teams to optimize performance
- Interact with your discovery or development teams providing professional external perspective
 

Additional Information

Experience
28 years at Rohm and Haas and DuPont (21 years Agrochemical Discovery, 7 years Central Research and Development)

Strength in Insecticide Discovery:
- Six novel insecticides commercialized with teams
- Led team in RT- PCR-based Listeria food pathogen detection technology, later commercialized

6.5 years in Biomass to Biofuels technologies- advanced cellulase/ hemicellulase consortium currently in pilot plants - define the problem first, then determine appropriate technologies including:

- Analytical chemistry
- Assay design; in vivo or in vitro, cell-based, enzyme or receptor assays
- HTS
- Structure-activity, molecular modifications, working with chemists/biologists/teams
- Biotechnology
- IP generation/protection
- Strategic planning to maximize business value
Honors and Awards
Keith D. Wing Consulting, LLC
Recipient 2015 Amer. Chem. Soc. AGRO Division International Award for Agrochemical Research for lifetime achievements in insecticide discovery, commercialization and science.

E. I. DuPont and Co. Agricultural Products Global Technology Accomplishment Awards

1991- Establishment of New Assays Leading to Discovery of Safer Insecticides

1992- Contributions in the Development of Mini-Metabolism Assays Leading to the Discovery of Safer Pesticides 1993- Contributions in the Development of Cell-Based Assays Leading to the Discovery of New Insecticides

1994- Contributions in the Development of “Small Sample Screens” Enhancing our Capability to Discover New Crop Protection Chemicals

1996- Outstanding Leadership, Innovation and Commitment to Achieving Step Change in Discovery Research

2002- Contributions to Optimization of a Potent New Class of Insecticides including E2Y45 Rynaxapyr (R) insecticide

2004- Contributions Leading to the Advancement of HGW86 Broad Spectrum Insecticide Cyazapyr (R) to Venture Qualification

2003- American Chemical Society Team Innovation Award- Discovery and Optimization of Indoxacarb (R) (co-awardee with S. McCann, G. Lahm, C. Harrison and R. Shapiro)

2003- Recipient of the DuPont Corporate Bolton-Carrothers Award for technical achievement towards a new product, Indoxacarb (R) (co-awardee with S. McCann, G. Lahm)

2011- Recipient of DuPont Volunteer Recognition Award for service on Charter School of Wilmington Board of Directors (one of many recipients for different community service)

Rohm and Haas Company Agricultural Products

1988- Received the Otto Haas Award for research elucidating the mode of action of a novel class of non-steroidal ecdysone agonist insecticide. (Highest scientific award at Rohm and Haas). (Compounds commercialized include Tebufenozide (R), Methoxyfenozide (R) and Halofenozide (R) )
Education
B.A. UCLA 1972-1976
PhD. UC Riverside/Davis 1976-1981
Postdoc UC Berkeley 1981-1983

Problem solving and strategic planning in agrochemical/insecticide discovery or life science biochemistry.
Strong track record of innovation and commercialization, 28 years industrial experience.
Patents
WO/2011/046818 (published 04/21/2011)
E. I. du Pont de Nemours and Company
Bazzana, Stephane F., Camp, Carl E., Fox, Bradley C., Schiffino, Rinaldo S., Wing, Keith D., Gonzalez, Yamaira
AMMONIA PRETREATMENT OF BIOMASS FOR IMPROVED INHIBITOR PROFILE

US Patent Application 20110250646 (published 10/13/2011)
E. I. du Pont de Nemours and Company
Bazzana, Stephane F., Camp, Carl E., Fox, Bradley C., Schiffino, Rinaldo S., Wing, Keith D.
AMMONIA PRETREATMENT OF BIOMASS FOR IMPROVED INHIBITOR PROFILE

WO/2011/046816 (published 04/21/2011)
E. I. du Pont de Nemours and Company
Schiffino, Rinaldo S., Wing, Keith D.
METHODS TO IMPROVE MONOMERIC SUGAR RELEASE FROM LIGNOCELLULOSIC
BIOMASS FOLLOWING ALKALINE PRETREATMENT

US Patent Application 20110250645 (published 10/13/2011)
E. I. du Pont de Nemours and Company
Schiffino, Rinaldo S., Wing, Keith D.
METHODS TO IMPROVE MONOMERIC SUGAR RELEASE FROM LIGNOCELLULOSIC
BIOMASS FOLLOWING ALKALINE PRETREATMENT

WO/2011/038019 (published 03/31/2011)
Danisco US INC./ E. I. du Pont de Nemours and Company
Bower, Benjamin, Hsi, Megan Y., Larenas, Edmund A., Kaper, Thijs, Kelemen, Bradley R., Lantz, Suzanne E., Mitchinson, Colin, Kim, Steven, Hitz, William D., Emptage, Mark, Wing, Keith D.
NOVEL GLYCOSYL HYDROLASE ENZYMES AND USES THEREOF

EP1085809 (published 03/28/2001)
E. I. du Pont de Nemours and Company
Leva, Michael D., McCann, Stephen F., Wing, Keith D.
ARTHROPODICIDAL CARBOXANILIDES

WO/1999/063825 (published 12/16/1999)
E. I. du Pont de Nemours and Company
Leva, Michael D., McCann, Stephen F., Wing, Keith D.
ARTHROPODICIDAL CARBOXANILIDES

US5708170 (issued 01/13/1998)
E. I. du Pont de Nemours and Company
Annis, Gary D., Barnette, William E., McCann, Stephen F., Wing, Keith D.
ARTHROPODICIDAL CARBOXANILIDES

US5602126 (issued 02/11/1997)
E. I. du Pont de Nemours and Company
Barnette, William E., Harrison, Charles R., Lahm, George P., Piotrowski, David W., Wing, Keith D.
ARTHROPODICIDAL ANILIDES

US5500438 (issued 03/09/1996)
E. I. du Pont de Nemours and Company
Barnette, William E., Harrison, Charles R., Lahm, George P., Piotrowski, David W., Wing, Keith D.
ARTHROPODICIDAL ANILIDES

US5462938 (issued 10/31/1995)
E. I. du Pont de Nemours and Company
Annis, Gary D., Barnette, William E., McCann, Stephen F., Wing, Keith D.
ARTHROPODICIDAL OXADIAZINYL, THIADIAZINYL AND TRIAZINYL CARBOXANILIDES

US5424333 (issued 06/13/1995)
Rohm and Haas Company
Wing, Keith D.
ANTHELMINTIC N'-SUBSTITUTED-N,N'-DISUBSTITUTEDHYDRAZINES

EP361645 (published 09/29/1993)
Rohm and Haas Company
Wing, Keith D.
ORGANIC HYDRAZINE DERIVATIVES FOR PHARMACEUTICAL USE
More Patents
PCT/US2012/029445 (filed 09/12/2013)
E. I. du Pont de Nemours and Company
Mitchinson, Colin, Kim, Steven S., Fujdala, Meredith K., Hsi, Megan Y., Wing, Keith D., Hitz, William D.
GLYCOSYL HYDROLASE ENZYMES AND USES THEREOF FOR BIOMASS HYDROLYSIS

PCT/US2012/029470 (filed 09/12/2013)
E. I. du Pont de Nemours and Company
Mitchinson, Colin, Li, Mian, Kelemen, Bradley R., Lantz, Suzanne E., Wing, Keith D., Hitz, William D.
METHOD FOR REDUCING VISCOSITY IN SACCHARIFICATION PROCESS

WO/1993/005024 (published 03/18/1993)
E. I. du Pont de Nemours and Company
Barnette, William E., Harrison, Charles R., Lahm, George P., Piotrowski, David W., Wing, Keith D.
ARTHROPODICIDAL ANILIDES

WO/1992/020682 (published 11/26/1992)
E. I. du Pont de Nemours and Company
Barnette, William E., Harrison, Charles R., Lahm, George P., Piotrowski, David W., Wing, Keith D.
ARTHROPODICIDAL ANILIDES
Publications
Wing, K.D., McCann, S., Andaloro, J.T., Salgado, V.L. (2004) Chapter 6.2: Indoxacarb and the Sodium Channel Blockers: Chemistry, Physiology and Biology. In: "Comprehensive Insect Physiology, Biochemistry, Pharmacology and Molecular Biology", eds. L. Gilbert, S. Gill, K. Iatrou

McCann, S.F., Annis, G.D., Shapiro, R., Piotrowski, D. W., Lahm, G. P., Long, J. K., Lee, K. C., Hughes, M. M., Myers, B. J., Griswold, S. M. Reeves, B. M., March, R. W., Sharpe, P. L., Lowder, P., Barnette W. E., Wing, K. D. (2001). The Discovery of Indoxacarb: Oxadiazines as a New Class of Pyrazoline-type Insecticides. Pest Management Science 57: 153-164.

Wing, K.D., Sacher, M., Connair, M., Mulderig, L., Schnee, M. (2000) Bioactivation and Mode of Action of the Oxadiazine Indoxacarb in Insects (2000) Crop Protection 19: 537-545.

Wing, K. D., Schnee M. E., Sacher, M., and Connair M. (1998). A Novel Oxadiazine Insecticide is Bioactivated in Lepidopteran Larvae. Arch. Insect Biochem. Physiol. 37:91-103.

Wing, K. D. and Aller, H. E. (1990). Ecdysteroid agonists as novel insect growth regulators, from International Symposium on Pesticides and Alternatives, Sept. 4-8, 1989, Kolymbari, Crete.

Wing, K. D. and Ramsay, J. R. (1989). Other hormonal agents: ecdysone agonists, from 1989 British Crop Protection Council Symposium: Reading, UK, “Progress and Prospects in Insect Control”, Monograph No. 43, pp. 107-118, Sept. 17-19, 1989.

Barton, A. E., Wing, K. D., Le, D., Slawecki, R. A., and Feyereisen, R. (1989). Arylpyridyl-thiosemicarbazones: a new class of anti-juvenile hormones active against the Lepidoptera. Experientia 45: 580-583.

Wing, K. D. (1988). RH5849, a non-steroidal ecdysone agonist: effects on a Drosophila cell line. Science 241: 467-469.

Wing, K. D., Slawecki, R. A., and Carlson, G. R. (1988). RH 5849, a nonsteroidal ecdysone agonist: effects on larval Lepidoptera. Science 241: 470-472.

Lidert, Z., Wing, K., Polonsky, J., Imakura, Y., Okano, M., Tani, S., Lin, Y.-M., Kiyokawa, H., and Lee, K.-H. (1987). Insect antifeedant and growth inhibitory activity of forty-six quassinoids on two species of agricultural pests. J. Natural Products 50:442-448.

Glickman, A. H., Wing, K. D., and Casida, J. E. (1984). Profenofos insecticide bioactivation in relation to antidote action and the stereospecificity of acetylcholinesterase inhibition, reactivation and aging. Toxicol. and Applied Pharmacol. 73: 16-22.

Wing, K. D., Glickman, A. H., and Casida, J. E. (1984). Phosphorothiolate pesticides and related compounds: oxidative bioactivation and aging of the inhibited acetylcholinesterase. Pestic. Biochem. and Physiol. 21:22-30.

Wing, K. D., Glickman, A. H., and Casida, J. E. (1983). Oxidative bioactivation of S-alkyl phosphorothiolate pesticides: stereospecificity of profenofos insecticide activation. Science 219: 63-65.
More Publications
Selby, T.P, Lahm, G.P., Stevenson, T.M., Hughes, K.A., Cordova, D., Bellin, C.A., Benner, E.A., Wing, K.D., Barry, J.D. Currie, M.J., Pahutski, T.F. Award Address (ACS Award for Team Innovation sponsored by the ACS Corporate Associates). Discovery of CyazypyrTM: A new anthranilic diamide rynanodine receptor activator for cross-spectrum control. Abst. 239th ACS National Meeting, San Francisco, CA, March 21-15, 2010, AGRO-3.

Selby, T.P, Lahm, G.P., Stevenson, T.M., Hughes, K.A., Cordova, D., Bellin, C.A., Benner, E.A., Wing, K.D., Barry, J.D. Currie, M.J., Pahutski, T.F. Discovery of Cyazypyr™: A new anthranilic diamide class of ryanodine receptor activators. Abst. 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008, AGRO-039.

McCann, S.F., Harrison, C.R., Lahm, G.P., Shapiro, R., Wing, K.D. The discovery and commercialization of IndoxacarbTM. Abst. 225th ACS National Meeting, New Orleans, LA, March 23-27, 2003, AGRO-057.

Hollingworth, R.M., Wing, K.D. Progress and prospects in the discovery of pesticides with novel mechanisms of action. Abst. 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000, AGRO-048.

Andaloro, J.T., Wing, K.D., Green, J.H., Lang, E.B. StewardTM dispersion and cotton leaf interactions: impact on cotton insect pests and safety to beneficial arthropods. In Proceedings of the 2000 Beltwide Cotton Conference, San Antonio, TX, January, 2000, pp. 939-940.

Flexner, L., Wing, K., Green, J., Cameron, R., Saienni, J., Williams, C. StewardTM rainfastness and residual control on cotton. In Proceedings of the 2000 Beltwide Cotton Conference, San Antonio, TX, January, 2000, pp. 940-942.

Tillman, G., Wing, K.D., Hammes, G., Sacher, M., Connair, M., Mulderig, L. Effect of StewardTM on Tarnished Plantbug and Big-Eyed Bug in cotton. In Proceedings of the 2000 Beltwide Cotton Conference, San Antonio, TX, January, 2000, pp. 1214-1216.

McCann, S.F., Annis, G.D., Shapiro, R., Long, J.K., Piotrowaski, D.W., Lee, K.C., Lahm, G.P., Highes, M.M., Myers, B.J., Griswold, S.M., Reeves, B.M., March, R.W., Sharpe, P.L., Barnette, W.E., Wing, K.D., Synthesis and biological activity of oxadiazines and triazine insecticide. The discovery of indoxacarb. Abst. 217th ACS National Meeting, Anaheim, CA, March 21-25. AGRO-031.
Miscellaneous
Tillman, P.G., Hammes, G.G., Sacher, M., Connair, M., Brady, E.A., Wing, K.D. (2001) Toxicity of a formulation of the insecticide Indoxacarb to the tarnished plant bug, Lygus lineolaris (Hemiptera: Miridae) and the big-eyed bug Geochoris punctipes (Hemiptera: Lygaeidae). Pest Manag. Sci. 58: 92-100.

Wing, K. D., Rudnicka, M., Jones, D., Jones, G., and Hammock, B. D. (1984). Juvenile hormone esterases of Lepidoptera II. Isoelectric points and binding affinities of hemolymph juvenile hormone esterase and binding protein activities. J. Comp. Physiol. B 154: 213 – 223.

Hammock, B. D., Wing, K. D., McLaughlin, J., and Sparks, T. C. (1982). Trifluoromethylketones as possible transition state analog inhibitors of juvenile hormone esterase. Pestic. Biochem. and Physiol. 17: 76-88.

Wing, K. D., Sparks, T. C., Lovell, V. M., Levinson, S. O., and Hammock, B. D. (1981). The compartmentalization and interrelationship of proteins influencing juvenile hormone metabolism in Trichoplusia ni. Insect Biochem. 11: 473-485.

Jones, G., Wing, K. D., Jones, D., and Hammock, B. D. (1981). The source and action of head factors regulating juvenile hormone esterase in larvae of the cabbage looper, Trichoplusia ni. J. Insect Physiol. 27: 85-91.

Hammock, B. D., Jones, D., Jones, G., Rudnicka, M., Sparks, T. C., and Wing, K. D. Regulation of juvenile hormone esterase in the cabbage looper, Trichoplusia ni, from International Conference on “Regulation of Insect Development and Behavior”, Part I, pp. 219 – 235. Tech. Univ. of Wroclaw, Karpacz, Poland, June 23-28, 1980. Scientific paper No. 22, Conference 7.

Wing, K. D., and Hammock, B. D. (1980). Immunochemical methods to detect pesticide residues. Calif. Agriculture 34: 34-35.

Sparks, T. C., Wing, K. D., and Hammock, B. D. (1979). Effect of the antihormone-hormone mimic ETB on the induction of insect juvenile hormone esterase in Trichoplusia ni. Life Science 25:445-450.

Wing, K. D., Hammock, B. D. (1979). Stereoselectivity of a radioimmunoassay for the insecticide S-bioallethrin. Experientia 35: 1619-1620.

Wing, K. D., Hammock, B. D., and Wustner, D. A. (1978). Development of an S-bioallethrin specific antibody. J. Agric. Food Chem. 26: 1328-1333.
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