“Hans Krebs, the Krebs Cycles and His Contributions to Amino
Acid Metabolism: A Personal Viewpoint”
Malcolm Watford, D.Phil.
Department of Nutritional Sciences, Rutgers University
Location: Frick Laboratory, Princeton University
Social mixer: 5:30 pm in CaFe, Taylor Commons
Presentation: 6:30 pm in Taylor Auditorium
Dinner: Immediately following presentation, in
Abstract: Hans A. Krebs was born in 1900 in Hildesheim, Germany and qualified in medicine in 1923. He began his scientific career in the laboratory of Otto Warburg (Nobel 1931) where he worked on tumor metabolism. When clinical duties limited his time for research, he moved in 1931 to the University of Freiberg. Over the next few years Krebs uncovered the basis of the ornithine (urea) cycle. When the government ended his academic appointment in 1933, he moved to Cambridge (UK) where he continued to work on amino acid metabolism. In 1935 at Sheffield University (UK) he elucidated the reactions of the citric acid cycle (tricarboxylic acid cycle, Krebs cycle). He was an awardee of the Nobel Prize in Physiology or Medicine in 1953 and then moved to Oxford where he completed work on the glyoxylate cycle.
One of Krebs’ main interests since the 1930’s was glutamine and glutamate metabolism. In what must be considered the foundation paper of glutamine metabolism in animals, he showed in 1935 that glutamine synthesis was an energy requiring reaction, and that there were two isozymes of glutaminase, brain-type and liver-type. Further investigations of
the tissue-specific metabolism of glutamine included its role as a substrate for gluconeogenesis in liver and kidney, its major function in providing urea and ammonia for excretion, and its role as a respiratory substrate in intestinal cells. Having worked until two weeks prior to his death in 1981, Hans A. Krebs is continually recognized not only for the Urea cycle and the Krebs cycle, but also for his contributions to amino acid metabolism that are now the foundations of
clinical therapies and also for extensive scientific investigation.
Biography: Malcolm Watford is a Professor of Nutritional Sciences at Rutgers University. He received his doctorate (D.Phil.) from Oxford University (UK) under the guidance of Sir Hans A. Krebs. He followed this with post-doctoral work at the Université de Montréal, Canada, and Case Western Reserve University and then served on the faculties of Nutrition and Biochemistry at Cornell University. He came to Rutgers in 1990 and is currently (since 2011) Director of the George H. Cook Scholars Program. His research interests are related to obesity and diabetes, lactation, and the comparative aspects of intermediary metabolism. Specifically he studies the tissue-specific metabolism of glutamine, and other amino acids, with particular emphasis on the relationship of gluconeogenesis and urea synthesis.
He currently serves on the Editorial Committee of the Annual Review of Nutrition and as Associate Editor for the Journal of Animal Science and Biotechnology, and the journal Animal Nutrition. An international educator, Professor Watford was honored in 2010 with the Excellence in Teaching Nutrition award from the American Society for Nutrition, and has received teaching awards from Hubei Province (China) and the Federal Government of Brazil. For 14 years he has served as a judge in the Siemens High School Competition for Science and Technology.
The meeting will be held in Frick Laboratory, Princeton University. The social mixer will begin in the atrium at 5:30 pm. The lecture will be held in the Auditorium at 6:30 pm followed by dinner in the CaFe area. Frick laboratory is located at the east end of the pedestrian bridge on Washington Rd, adjacent to the Weaver Track and Field Stadium. Parking is available in Lot 21, corner of Faculty Road and Fitzrandolph Road or other lots along Ivy Lane (see http://m.princeton.edu/map/). The seminar is free and open to the public. Reservations are required for dinner, which is $20 ($10 for students). Please contact Louise Lawter at firstname.lastname@example.org or 215-428-1475 by January 21 to make reservations. Reservations must be canceled no later than January 26 to avoid being billed for the dinner.