“Systems Pharmacology Modeling: A Bridging Tool for Engineering and Optimizing Drug R&D Plans”
Jeffrey Barrett, Ph.D
Location: Frick Laboratory, Princeton University
Social mixer: 5:30 pm in CaFe, Taylor Commons
Presentation: 6:30 pm in Taylor Auditorium
Dinner: Immediately following presentation, in
Abstract: Systems pharmacology seeks to understand how medicines work on various biologic systems of the body. Instead of considering the effect of a drug to be the result of one specific drug-protein interaction, systems pharmacology considers the effect of a drug to be the outcome of a network of interactions. Such networks may include chemical-protein, protein-protein, genetic, signaling and physiological (at cellular, tissue, organ and whole body levels) representations. Systems pharmacology uses bioinformatics and statistics techniques to integrate and interpret these
networks. The adoption of systems pharmacology into mainstream drug development is part of a broad emphasis on utilizing quantitative approaches to facilitate improved decision making.
While system pharmacology models serve many purposes, their ability to conceptualize and quantify the salient elements defining a new chemical entity’s mechanism of action is of primary importance. At their core, these models are often defined by hundreds of ordinary differential equations (ODEs) and thousands of parameters. It is incumbent upon the scientists developing such models to ensure pharmacologic plausibility and clinical credibility in order to garner confidence from the project teams reliant on their output. Likewise, the appropriate treatment of variability and uncertainty must be made in order to establish virtual patient phenotypes that mimic patient response to therapy. The process by which these models are developed and communicated is presented along with illustrations of how these models impact drug development decisions.
Dr. Jeff Barrett is Vice President and Global Head of the Interdisciplinary Program in Pharmacometrics
Program (IPP) and Global Head of Pediatric Clinical Pharmacology at Sanofi. In this role he leads the modeling and simulation efforts across the scientific core platforms - developing, testing, and exploiting quantitative relationships to facilitate critical decisions that span the drug discovery and development process. Dr. Barrett spent the previous 10+ years at the University of Pennsylvania where he was Professor, Pediatrics and Director, Laboratory for Applied PK/PD at the Children’s Hospital of Pennsylvania (CHOP). His academic career was highlighted by sustained NIH support for pharmacometric research across numerous therapeutic areas in both adult and pediatric populations. He continues to serve as an Adjunct Professor of Pediatrics at Penn School of Medicine.
Dr. Barrett received his BS in Chemical Engineering from Drexel University and PhD in Pharmacokinetics from the University of Michigan. He is a fellow of the American College of Clinical Pharmacology (ACCP) and American Assoc. of Pharmaceutical Scientists (AAPS) and the recipient of numerous honors including ACCP awards for Young Investigator (2002) and Mentorship in Clinical Pharmacology (2007), and the 2013 Exceptional Innovation Award of the International Society for Pharmacometrics. In 2013, he was the acting chair of the FDA Advisory Committee for Pharmaceutical Science and Clinical Pharmacology. He serves on the Editorial Boards of the Journal of Pharmacokinetics and Pharmacodynamics and Pharmacometrics & Systems Pharmacology.
The meeting will be held in Frick Laboratory, Princeton University. The social mixer will begin in the atrium at 5:30 pm. The lecture will be held in the Auditorium at 6:30 pm followed by dinner in the CaFe area. Frick laboratory is located at the east end of the pedestrian bridge on Washington Rd, adjacent to the Weaver Track and Field Stadium. Parking is available in Lot 21, corner of Faculty Road and Fitzrandolph Road or other lots along Ivy Lane (see http://m.princeton.edu/map/). The seminar is free and open to the public. Reservations are required for dinner, which is $20 ($10 for students). Please contact Louise Lawter at firstname.lastname@example.org or 215-428-1475 by
February 18 to make reservations. Reservations must be canceled no later than February 23 to avoid being billed for