Publications
Selected Publications: Allosteric Modulators of G Protein-Coupled Receptors. Wells, G. J. (Ed.); Kuduk, S. D.; Beshore, D. C.; Huang, X.; Dale, E.; Brodbeck, R. M.; Doller, D.; Szabo, G.; Keseru, G. M.; Hao, J.; Xiong, H.; Hurevich, M.; Talhami, A.; Shalev, D. E.; Gilon, C.; Curr. Topics Med. Chem., 14, 1735-1863 (2014). Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1-f][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors. Mesaros, E. F.; Thieu, T. V.; Wells, G. J.; Zificsak, C. A.; Wagner, J. C.; Breslin, H. J.; Tripathy, R.; Diebold, J. L.; McHugh, R. J.; Wohler, A. T.; Quail, M. R.; Wan, W.; Lu, L.; Huang, Z.; Albom, M. S.; Angeles, T. S.; Wells-Knecht, K. J.; Aimone, L. D.; Cheng, M; M. A.;Ator, Ott, G. R.; Dorsey, B. D.; J. Med. Chem., 55, 115 125 (2012). 2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation. Weinberg, L. R.; Albom, M. S.; Angeles, T. S.; Breslin, H. J.; Gingrich, D. E.; Huang, Z.; Lisko, J. G.; Mason, J. L.; Milkiewicz, K. L.; Thieu, T. V.; Underiner, T. L.; Wells, G. J.; Wells-Knecht, K. J.; Dorsey, B. D.; Bioorg. Med. Chem. Lett., 21, 7325-7330 (2011). 2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation. Wells-Knecht, K. J.; Ott, G. R.; Cheng, M.; Wells, G. J.; Breslin, H. J.; Gingrich, D. E.; Weinberg, L.; Mesaros, E. F.; Huang, A.; Yazdarian, M.; Ator, M. A.; Aimone, L. D.; Zeigler, K.; Dorsey, B. D.; Chem. Res. Tox., 24, 1994-2003 (2011). 2,7-Disubstituted-pyrrolo[2,1-f][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitumor Activity. Ott, G. R.; Wells, G. J.; Thieu, T. V.; Quall, M. R.; Lisko, J. G.; Mesaros, E. F.; Gingrich, D. E.; Ghose, A. K.; Wan, W.; Lu, L.; Cheng, M.; Albom, M. S.; Angeles, T. S.; Huang, Z.; Aimone, L. D.; Ator, M. A.; Ruggeri, B. A.; Dorsey, B. D.; J. Med. Chem., 54, 6328-6341 (2011). Synthesis and Structure-Activity Relationships of Novel Pyrrolocarbazole Lactam Analogs as Potent and Cell-permeable Inhibitors of Poly(ADP-ribose)polymerase-1 (PARP-1). Wells, G. J.; Bihovsky, R.; Hudkins, R. L.; Ator, M. A.; Husten, J.; Bioorg. Med. Chem. Letters, 16, 1151-1155 (2006). Synthesis and Structure-Activity Relationships of Novel Poly(ADP-ribose)polymerase-1 Inhibitors. Tao, M.; Park, C. H.; Bihovsky, R.; Wells, G. J.; Husten, J.; Ator, M. A.; Hudkins, R. L.; Bioorg. Med. Chem. Letters, 16, 938-942 (2006). 1,2-Benzothiazine 1,1-dioxide -Ketoamide analogues as potent Calpain I Inhibitors. Bihovsky, R.; Tao, M.; Mallamo, J. P.; Wells, G. J.; Bioorg. Med. Chem. Letters, 14, 1035-1038 (2004).