CHEMICAL CONSULTANTS NETWORK

Youwen Xu

CCN

 

Member profile details

Photo
First name
Youwen
Last name
Xu
Organization
CCN
 

Contact information

City
Philadelphia
State or Province
Pennsylvania
Zip Code
19131
Country
United States
Phone
631-384-2864
 

Specialties and Services

Fields of Expertise
  • Analytical
  • Biotechnology
  • High Performance Liquid Chromatography
  • Nuclear Chemistry
  • Pharmaceutical
  • Product Development
  • Project Management
  • Regulatory Affairs
  • Research and Development
  • Separations and Purification
  • Spectroscopy
  • Synthesis
  • Technology Transfer
  • Validation
Other Fields of Expertise
PET tracers and therapeutics development and validation in academic and industry settings;
Experienced with bio-imaging tools and their use for bio-distribution, PK/PD studies, ...,
Experienced with cGMP compliance and clinical trials
Services
PET technology application for drug development and disease mechanism studies
PET tracer and radio therapeutics development and validation
Small animal in vivo and in vitro imaging and data analysis
Bio-distribution and metabolic mechanism study of radio labeled compounds
Compound purification with HPLC, SPE methods
Experimental SOP and study protocol development and edition
Clinical trial preparation

API custom synthesis
Hot lab operation and personnel training for radioactive material handling and instrument operation
 

Additional Information

Experience
INDEPENDENT CONSULTANT/CONTRACTOR, PHILADELPHIA, PA 2018 to Current

 Radiopharmaceutical development, validation and application
Small molecule and macro molecule labeling and validation
In vivo, in vitro small animal imaging and data analysis
Technology transfer

Eli Lilly and Company, PHILADELPHIA, PA 2016 to 2018

Senior Radiochemist, Radiochemistry Support Team Lead for Discovery Research, 2017 to 2018
 Cross-function interactions and communication for project planning, scheduling and progress updating
 PET tracer development for Alzheimer’s Disease study
Senior Radiochemist, 2016 to 2017
 Radiopharmaceutical manufacturing process development for product commercialization

BROOKHAVEN NATIONAL LABORATORY (BNL), Radiochemistry, Instrumentation and Bio-imaging Program, Upton, NY 2001 to 2015
Radiochemist & Document Control Coordinator for PET tracer development and validation for clinical and pre-clinical, and plant studies. cGMP compliance.

LOS ALAMOS NATIONAL LABORATORY, Los Alamos, NM 1998 to 2001
Staff Research Associate
Spectroscopic study of solution and solid state species
Honors and Awards
 Recipient, Leadership training, Avid Radiopharmaceuticals Inc / Eli Lilly and Company
 Recipient, Brookhaven National Laboratory Spot Light Award
 Member, American Chemical Society (ACS), Chemical Consulting Network (CCN)
 Member, American Institute of Chemical Engineers (AIChE)
 Member, Society for Radiopharmaceutical Sciences (SRS)
 Member, Society of Nuclear Medicine and Molecular Imaging (SNMMI)
 Member, American Association for the Advancement of Science (AAAS)
 Member, New York Academy of Sciences (NYAS), endorsed by SUNY SBU
 Trained and qualified by Compliance Solutions Incorporated for cGMP Compliance
Education
 Doctor of Philosophy (PhD) (completion), PET chemistry and application, Stony Brook University, NY / Brookhaven National
Laboratory (BNL), Upton, NY
 Master of Science (MSc), Chemistry, Tuskegee University, AL / Los Alamos National Laboratory (LANL), NM
Publications
 Xu Y, Li Z. Imaging Metabotropic Glutamate Receptor (mGluR) System: Application of PET Technology in Drug Development. Med Res Rev. 2019, 39(5):1892-1922. doi: 10.1002/med.21566. Epub 2019 Feb 10.
 Xu Y, ..., Fowler J, Qu W. Synthesis of L-[4-11C]-Asparagine via Ring-Opening Nucleophilic [11C]Cyanation Reaction of a Chiral Cyclic Sulfamidate Precursor. Chem Eur J 2018, 24(26), 6848-6853.
 Qu W, ..., Xu Y, et al. Dynamic Precision Phenotyping Reveals Mechanism of Crop Tolerance to Root Herbivory. Plant Physiol. 2016,172(2), 776-788.
 Xu Y, ..., Fowler J. A Mild, Rapid Synthesis of Freebase [11C]nicotine from [11C]methyl Triflate. Appl Radiat Isot 2016, 118, 62-66.
 Pankievicz, ...., Xu, Y., et al. A. Robust Biological Nitrogen Fixation in a Model Grass–bacterial Association. Plant J 2015, 81, 907-919.
 Fowler J, ..., Xu Y et al. Evidence that Formulations of the Selective MAO-B Inhibitor, Selegiline, which Bypass First-Pass Metabolism, also Inhibit MAO-A in the Human Brain. Neuropsychopharmacology 2015, 40, 650-657.
 Xu Y, ..., Fowler J. Radiosynthesis of 3-Indolyl[1-11C]Acetic Acid for in vivo Plant Imaging: An Improved Production Procedure and Formulation Method. Appl Radiat Isot 2014, 91, 155-160.
 Pareto D, ..., Xu Y,..., Logan J. In vivo Imaging of Brain Aromatase in Female Baboons: [11C]Vorozole Kinetics and Effect of the Menstrual Cycle. Mol Imaging 2013, 12(8), 518-524.
 Sharma R, Xu Y, et al. Carbon-11 Radiolabeling of Iron-oxide Nanoparticles for Dual-modality PET / MR Imaging. Nanoscale, 2013, 5(16):7476-7483.
 Riss PJ,..., Xu Y, et al. Characterization of [11C]PR04.MZ in Papio Anubis Baboon: A Selective High-Affinity Radioligand for Quantitative Imaging of the Dopamine Transporter. Bioorganic Med Chem Lett 2012, 22(1), 679-682.
 Logan J, ..., Xu Y, et al. Blockade of the Brain Histamine H3 Receptor by JNJ-39220675: Preclinical PET Studies with [11C] GSK189254 in Anesthetized Baboon. Psychopharmacology (Berl). 2012, 223(4), 447-455.
 Li Z, Xu Y, Warner D, & Volkow N. Alcohol ADME in Primates Studied with Positron Emission Tomography. PLoS ONE, 2012, 7(10):e46676.
 Li L, Xu Y, et al. Radiosynthesis and Bioimaging of the Tuberculosis Chemotherapeutics Isoniazid, Rifampicin and Pyrazinamide in Baboons. J Med Chem 2010, 53(7), 2882-2891.
 Fowler J, ..., Xu Y, et al. Reversible Inhibitors of Monoamine Oxidase-A (RIMAs): Robust, Reversible Inhibition of Human Brain MAO-A by CX157. Neuropsychopharmacology 2010, 35, 623-631.
 Hooker J, ..., Xu Y, et al. Histone Deacetylase Inhibitor MS-275 Exhibits Poor Brain Penetration: Pharmacokinetic Studies of [11C]MS-275 Using Positron Emission Tomography. ACS Chem Neurosci 2010, 1, 65-73.
 Hooker J, ..., Xu Y, et al. Salvinorin A and Derivatives: Protection from Metabolism does not Prolong Short-Term, Whole-Brain Residence. Neuropharmacology 2009, 57(4):386-391.

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More Publications
 Kim SW, ..., Xu Y, et al. Reinvestigation of the Synthesis and Evaluation of [N-Methyl-11C]Vorozole, a Radiotracer Targeting Cytochrome P450 Aromatase. Nucl Med Biol 2009, 36(3), 323-334.
 Reid A, ..., Xu Y, et al. Evaluation of 6-([18F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain. Nucl Med Biol 2009, 36(3), 247-258.
 Volkow N, ..., Xu Y, et al. Effects of Modafinil on Dopamine and Dopamine Transporters in the Male Human Brain. Clinical Implications. JAMA, J Am Med Asso 2009, 301(11), 1148-1154.
 Hooker J, ..., Xu Y, et al. Pharmacokinetics and Pharmacodynamics of the Potent Hallucinogen, Salvinorin A. J Nucl Med 2008, 49 (Suppl 1):210P.
 Reid A, ..., Xu Y, Fowler J. Comparison of the Pharmacokinetics of Different Analogs of 11C-Labeled TZTP for Imaging Muscarinic M2 Receptors with PET. Nucl Med Biol 2008, 35(3), 287-298.
 Hooker J, Xu Y, et al. Pharmacokinetics of the Potent Hallucinogen, Salvinorin A in Primates Parallels the Rapid Onset and Short Duration of Effects in Humans. NeuroImage 2008, 41(3), 1044-1050.
 Fowler J, ..., Xu Y, et al. Fast Uptake and Long-Lasting Binding of Methamphetamine in the Human Brain: Comparison with Cocaine. NeuroImage 2008, 43(4), 756-763.
 Fowler J, ..., Xu Y, et al. PET Studies of d-Methamphetamine Pharmacokinetics in Primates: Comparison with l-Methamphetamine and (-)-Cocaine. J Nucl Med 2007, 48(10), 1724-1732.
 Logan J, ..., Xu Y, et al. Imaging the Norepinephrine Transporter in Humans with (S,S)-[11C]O-Methyl Reboxetine and PET: Problems and Progress. Nucl Med Biol 2007, 34(6), 667-679.
 Kim SW, ..., Xu Y, et al. Synthesis and Positron Emission Tomography Studies of C-11-Labeled Isotopomers and Metabolites of GTS-21, a Partial α 7 Nicotinic Cholinergic Agonist Drug. Nucl Med Biol 2007, 34(5), 541-551.
 Kil K-E, ..., Xu Y,et al. Synthesis and Positron Emission Tomography Studies of Carbon-11-Labeled Imatinib (Gleevec). Nucl Med Biol 2007, 34(2), 153-163.
 Fowler J, ..., Xu Y, et al. Comparison of Monoamine Oxidase A in Peripheral Organs in Nonsmokers and Smokers. J Nucl Med 2005, 46(9), 1414-1420.
 Ding Y-S, ..., Xu Y, et al. Brain Kinetics of Methylphenidate (Ritalin) Enantiomers after Oral Administration. Synapse 2004, (53)168-175.
 Fowler J, ..., Xu Y, et al. Comparison of the Binding of the Irreversible Monoamine Oxidase Tracers: [11C]Clorgyline and [11C]l-Deprenyl in Brain and Peripheral Organs in Humans. Nucl Med Biol 2004, 31(3), 313-319.
 Ding, Y-S; ... Xu Y, et al. Evaluation of a New Norepinephrine Transporter PET Ligand in Baboons, both in Brain and Peripheral Organs. Synapse 2003, 50(4), 345-352.
 Fowler J, ..., Xu Y, et al. Low Monoamine Oxidase B in Peripheral Organs in Smokers. Proc Natl Acad Sci USA 2003, 00(20), 11600-11605.
 Fowler J,..., Xu Y, et al, Monoamine Oxidase A Imaging in Peripheral Organs in Healthy Human Subjects. Synapse 2003, 49(3), 178-187.

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Miscellaneous
additional publications, research reports, national and international conference presentations......
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