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The Body, Not the Brain, Regulates Sleep

15 Aug 2023 4:02 PM | Youwen Xu (Administrator)

Sleep, the black box of biology, is regulated by three key genes that are not in the brain, but in peripheral tissues. The findings demonstrate that sleep is all about protein homeostasis: endoplasmic reticulum (ER) stress and downregulation of protein biosynthesis in peripheral tissues trigger pathways that induce sleep. 

ER PROTEOSTASIS REGULATORS CELL-NON-AUTONOMOUSLY CONTROL SLEEP

KAWANO, TAIZO ET AL. CELL REPORTS, 42(3), 112267.  :https://doi.org/10.1016/j.celrep.2023.112267


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