I will be presenting a 3-part webinar series on mixing technology in April, May, and June 2019 as part of a project I have with DynoChem.  Registration information is below.

Talking Mixing:  Basics of Mixing - April 24, 2019, 9AM-10AM EDT
Don’t be “baffled” by mixing.  Tune in for some mixing basics that will be the foundation for us to examine some challenging mixing applications.  In this webinar we will cover power, flow, “shear” (the most mis-used term in mixing), blending of miscible liquids, baffles, and an initial look at scale-up and scale-down. 

Talking Mixing:  Multiphase Mixing – May 29, 2019, 9AM-10AM EDT
Solid-liquid, liquid-liquid, and gas-liquid systems create some mixing challenges.  The second webinar will show a common framework for thinking about these systems as well as some specific ways to estimate and scale process responses.

Talking Mixing:  Reactive Mixing – June 19, 2019, 9AM-10AM EDT
This third webinar will tie together the concepts from the first two sessions as we look at competing rate processes, how we can understand the role of mixing in our process, and how to scale our mixer to deliver our desired process response.

Register for the each of the free one-hour webinars at DynoChem Resources (https://dcresources.scale-up.com/default.aspx#HOME)
or search there for Sarafinas:  https://dcresources.scale-up.com/default.aspx#q=Sarafinas
You may need to register with DynoChem before registering for the webinars.

All webinars will be recorded and posted on DynoChem Resources.

Thanks,
Aaron

From Joe Martino

April 11:  Joseph Priestly Society Meeting

Time:  11:30 AM -- 2:30 PM

Place:  Science History Institute

            315 Chestnut Street

            Philadelphia, PA 19106

Speakers:  Sandra Donovan (Donovan Associates)

                   Maria L. Maccecchini (QR Pharma, Inc.)

                   Yaniv Sneor (Blue Cactus Consulting)

Topic:  "Angel and Venture-Capital Investment in Biotech and Health Care"

Cost:  $25.00

Registration:  On-line

Website:  http://bit.ly/2XFiYiw

April 15:  ACS Philadelphia Section Meeting / Student Banquet

Time:  6:00 PM -- 9:00 PM

Place:  Lathem Hall

            East 13th and Potter Streets

            Chester, PA 19013

Speaker:  Loyd Bastin (Widener University)

Topic:  "Speaking for the trees:  An academic career focused on sustainability education"

Cost:  $25.00

Registration:  On-line

Website:  https://acsphillystudentbanquet2019.eventbrite.com

April 18:  Philadelphia Organic Chemists Club Meeting

Time:  6:30 PM -- 8:30 PM

Place:  Chemistry Building

             University of Pennsylvania

             34th and Spruce Streets

             Philadelphia, PA

Speaker:  Dustin J. Mergott (Eli Lilly and Company)

Topic:  TBD
Cost:  $20.00 to join POCC

Registration:  On-line to join POCC

Website:  http://www.pocclub.org/

April 23-24:  Chemical Ventures Conference 2019

Place:  Delaware Innovation Space

             200 Powder Mill Road

             Wilmington, DE 19803

Agenda:  A two-day conference focusing on innovation, investment and deal flow in the chemical space.

Cost:  $95.00 to $795.00, depending on category

Registration:  On-line

Website:  https://www.aiche.org/conferences/chemical-ventures-conference/2019

Meeting of the Princeton ACS Section, Thursday, March 21, 2019 

Bart Devolder, Conservator, Princeton University Art Museum will speak on  "Painting Conservation; more than cleaning pictures"
Frick Chemistry Laboratory, Princeton University, Mixer 5:30 pm; Lecture 6:30 pm followed by dinner

Abstract: Bart Devolder will discuss the diverse tasks and competencies that fall under the job description of Painting Conservator. In this lecture, he will also explain some of his past conservation projects. Bart will also present some of the initial planning and ideas for the new Conservation Lab and Department of the Princeton University Art Museum, which is part of the new expanded museum building project slated for completion in 2023.

Biography: Bart J.C. Devolder received his M.A. in painting conservation from the Royal Academy of Fine Arts, Antwerp, Belgium, in 2002. He held internships at the Akademia Sztuk Pieknych, Krakow, Poland, the Royal Institute for Cultural Heritage (KIK-IRPA), Brussels, and the Musée du Louvre, Paris. Bart also received a fellowship from the Straus Center for Conservation at the Harvard University Art Museums (2003–4) and was the Andrew W. Mellon Fellow in Painting Conservation at the National Gallery of Art, Washington, D.C. (2004–7).

Bart has worked for the Kimbell Art Museum and Amon Carter Museum of American Art in Fort Worth, Texas, first as assistant conservator of paintings (2007–10) and later as associate conservator of paintings (2010–12). Before joining the Princeton University Art Museum as conservator of collections in the summer of 2018, he was the on-site coordinator and painting conservator for the restoration of the Ghent Altarpiece by the brothers Hubert and Jan van Eyck (2012–18).

Reservations: The meeting will be held in Frick Laboratory, Princeton University. The social mixer will begin at 5:30 pm in the CaFe area of Taylor Commons. The lecture will be held in the Auditorium (B02) at 6:30 pm followed by dinner in Taylor Commons (CaFe area).  Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd, adjacent to the Weaver Track and Field Stadium. Parking is available in Lot 21, corner of Faculty Road and Fitzrandolph Road or other lots along Ivy Lane after 5:00 pm. (see http://m.princeton.edu/map/.  The seminar is free and open to the public. Reservations are encouraged for the seminar but required for dinner, which is $25 for members ($22.50 if prepaid online) and $10 for students. By March 16, please register and prepay at http://chemists.princeton.edu/pacs/event/princeton-acs-meeting-thursday-march-21-2019/.  If you have questions, contact louise.lawter@gmail.com.

Interested in Pittcon?

March 17-21, 2019     Pennsylvania Convention Center, Philadelphia

Get 50% off registration using the discount code 19CCN

Go to https://pittcon.org/register/

Keith Wing, Chair CCN

From: Debbie Blough <debbie.blough@bblumberg.org>
Date: Wed, Dec 12, 2018 at 2:29 PM
Subject: FW: Announcing Drug Design Lecture Series with Nicholas Meanwell
To: debbie.blough@bblumberg.org. <debbie.blough@bblumberg.org>

Good Afternoon:

Announcing a new lecture series titled Topics in Drug Design, hosted by Nicholas A. Meanwell, Ph.D.  Beginning January 8 and running through 2019, Dr. Meanwell will deliver 6 lectures on drug design.  Lectures are from 4 – 5 PM, and will be in Room 100 at the PA Biotechnology Center, 3805 Old Easton Road, Doylestown, PA 18902. Please join us – and feel free to forward this announcement to your colleagues!

Dr. Meanwell has a Ph.D. from the University of Sheffield and completed a Postdoctoral Fellowship at Wayne State University. He joined Bristol-Myers Squibb in 1982 and has led the antiviral chemistry group since 1992. They have pioneered several mechanistically novel antiviral approaches including influenza and respiratory syncytial virus fusion inhibitors, HIV-1 attachment inhibitors and HCV NS5A inhibitors. They have also completed Phase 3 clinical trials of a combination of the HCV NS5A inhibitor daclatasvir and the HCV NS3 inhibitor asunaprevir.

The Princeton ACS Local Section, in conjunction with the Division of Small Chemical Business will be hosting an Entrepreneurial Symposium on December 19, 2018.  The theme of the symposium is “Advancing Innovation and Entrepreneurship: Innovate Now – Launch, Leverage, Lead”.  The Symposium and Dinner will also serve as the December Meeting of the Princeton ACS Section.  Information can be found on our website at http://chemists.princeton.edu/pacs/monthly-meeting/joint-acs-division-of-small-chemical-business-princeton-section-entrepreneurship-symposium/

From Joe Martino.

Greetings to all!  Here's the list of meetings for the month of December:

December 11:  The Chromatography Forum of Delaware Valley Monthly Meeting

Time:  6:00 PM -- 8:30 PM

Place:  DiFabios Events

             1243 N. Providence Road

             Media, PA 19603

Speaker:  Kevin Schug (The University of Texas at Arlington)

Topic:  "GC-VUV Advances and Applications"

Cost:  $30.00

Registration:  On-line

Website:  http://www.cfdv.org/meetings/The+Role+of+Vacuum+Ultraviolet+Spectroscopy+in+the+Gas+Chromatography+Detector+Pantheon

December 13:  Philadelphia Drug Discovery Forum Meeting -- Biacore User Day

Time:  8:30 AM to 4:00 PM

Place:  The Wistar Institute

             3601 Spruce Street

             Philadelphia, PA 19104

Speakers:  Brian Lang (GE Healthcare)

                   Megan Meuser (Drexel University)

                   Daniel Kulp (The Wistar Institute)

                   Sai Kiran Sharma (Memorial Sloan Kettering Cancer Center)

                   Sumana Chandramouli (GSK Vaccines)

                   Mingzhu He (Center for Molecular Innovation)

                   Marc Raphael (US Naval Research Laboratory)

                   Michael Murphy (GE Healthcare)

Topic:  An overview of GE Healthcare's Biacore instrumentation

Cost:  Free

Registration:  On-line

Website:  http://landing1.gehealthcare.com/BUD2018-Philadelphia.html?utm_source=FLYER

Cheers!  Joe

For details and to register, go to

https://aiche-philadelphia.org/events/2018-events/october-25-2018-oktoberfest/

Come celebrate the 2018 AIChE DVS Annual Oktoberfest on Thursday October 25th, from 6:30-9:30pm. For 7 years now, the AIChE Delaware Valley Section has celebrated our annual Oktoberfest at Yards. Now in 2018, Yards has moved to a new facility and AIChE-DVS is happy to celebrate at their new venue. The new bigger and better location is at 5th and Spring Garden (500 Spring Garden Street Philadelphia, PA 19123), with parking available on-site. Join us for a few local craft beers, delicious food, and tours of the new facility. Professionals and students (21+) alike are all welcome.

Date: Thursday October 25, 2018
Time: 6:30-9:30 (taproom will be open until 11 pm)

Registration deadline: Please register as soon as possible, or by October 17th.

Prices:
$45: Regular (non-member) Attendees
$40: AIChE DVS Members
$30: Young Professionals (under 35)
$20: Students (Undergraduate and Graduate Students welcome)

This will be an interesting expert panel discussion Nov. 8, 2018, 11:30 am, sponsored by the Joseph Priestley Society of the Science History Institute.  For details and to register go to   https://www.sciencehistory.org/event/joseph-priestley-society-201811

Please join us on October 16 to recognize Clarissa Forneris and Kevin Speina, the 2018 winners of the Graduate Student Awards presented by Princeton ACS Section. 

Princeton ACS Meeting & Graduate Student Awards Seminar - Tuesday October 16, 2018  http://chemists.princeton.edu/pacs/monthly-meeting/princeton-acs-october-16-meeting-announcement/

Frick Chemistry Laboratory, Princeton University - Mixer 5:30pm; Presentation 6:30pm; Dinner 7:45pm

Our speakers will be Clarissa Forneris and Kevin Speina:

Clarissa Forneris - "In Vitro Reconstitution of Native P450s Activities Enables Total Chemo-Enzymatic Syntheses of Vancomycin Aglycone Variants”

Abstract: Glycopeptide antibiotics (GPAs) are indispensible for the treatment of life-threatening infections caused by Gram-positive bacteria, especially methicillin-resistant S. aureus. The founding member of this antibiotic class, vancomycin, has been in clinical use since 1948 and, to this date, it is known as the drug of last resort. As inevitable resistance to current antibiotics spreads among pathogenic bacteria, it will be necessary to have a constant supply of new treatments to replace them. Synthetic derivatization of known natural products is the most successful way to create more potent antibiotics, but this approach has been restricted within the GPAs, due to their size and chemical complexity. Three post-translational modifications (PTMs) to the GPA core peptide provide functional shape and rigidity to the molecule. In vancomycin, two bisaryl ether crosslinks and a biaryl carbon-carbon bond are installed by the cytochrome P450 enzymes OxyB, OxyA and OxyC, in this order. It has been hypothesized that if the enzymatic activity of these enzymes could be reconstituted in vitro, a route to the facile synthesis of vancomycin and analogs would be opened. Our work toward achieving this goal will be described.

Biography: Clarissa is a 5th year graduate student in the group of Prof. Seyedsayamdost at Princeton University. She is a native of Brazil and moved to Cambridge, MA to carry out her undergraduate studies at Massachusetts Institute of Technology (MIT), where she received a B.S. in Chemistry in 2013. While at MIT, she worked with Prof. Danheiser on synthetic applications of benzannulation reactions. During her graduate studies, she has developed a chemo-enzymatic strategy to synthesize vancomycin, the antibiotic of last resort, and its analogs.


Kevin Speina - "Towards Commodity Scale Production of Ketones Using a Resilient Fungal Heme Protein"

Abstract: The non-reactive nature of aliphatic C-H bonds makes catalytic oxyfunctionalization, under ambient conditions profoundly difficult. Overcoming this challenge has the potential of transforming low cost, abundant hydrocarbons (i.e. methane, cyclooctane) into low cost precursor molecules capable of derivatization; an industrially advantageous enterprise. Fortunately, nature evolved enzymatic catalysts able to perform oxygenation onto relatively inert C-H bonds. Cytochrome P450s (P450) are a class of monooxygenases that incorporate molecular oxygen onto aliphatic C-H bonds with remarkable regio and stereoselectivity. Within the P450 active site lies an iron protoporphyrin IX with a cysteinate axial ligand. Unfortunately, P450 enzymes require a prohibitively expensive cofactor NAD(P)H and reductases to perform C-H activation chemistry. A class of enzymes known as fungal aromatic peroxygenases (APOs) circumvents this limitation by using H202 as a co-substrate to perform C-H functionalization reactions. APO enzymes are stable, extracellular, glycosylated proteins that have no sequence homology to P450 analogs, yet have enhanced reactivity to P450 enzymes.. Our work with a recently identified APO from Marasmius rotula [MroAPO] will be described.


Biography: Kevin Speina is a graduate student in the at Princeton University, currently pursuing his PhD in bioinorganic chemistry.  He graduated from Manhattan College with a BS in Chemistry and minors in philosophy, religion, and mathematics.  His interest in green chemistry and entrepreneurship have kindled a passion for pursuing research and development; particularly focused on bringing products from lab bench to market.  He speaks Portuguese, Spanish, Polish and English and is now studying Chinese in order to negotiate with fellow entrepreneurs  and begin in  investing in the Chinese Belt and Road Initiative.


Reservations: The meeting will be held in Frick Laboratory, Princeton University. The mixer will begin at 5:30 pm in the Taylor Commons. The lecture will be held in the Auditorium at 6:30 pm followed by dinner in CaFe area of Taylor Commons. Parking is available in Lot 21 or other lots along Ivy Lane (see http://m.princeton.edu/map/).. The seminar is free and open to the public. Reservations are required for dinner, which is $20 ($10 for students). Please contact Louise Lawter at louise.lawter@gmail.com or 215-428-1475 by October 11 to make reservations. Reservations must be canceled no later than October 15 to avoid being billed for the dinner.